AIPMT 2008 Physics and Chemistry Paper

The relative reactivities of acyl compound towards nucleophilic substitution will depend upon the nature of leaving group ability. Weak bases are good leaving group.

Cl−<R− O || C −O−<R−O−< .. N H2 ───────────────────────────────────▶

Basic strength increases

∴

Cl−>R−C−O−>R−O−> .. N − H2 ───────────────────────────────────▶

Leaving group abilities increases

R−

O ||

C

−OR>R−

O ||

C

−NH2