IBPS Clerk Mains 8 Oct 2022 Paper

In the sentence, certain words are in bold and numbered from A to E, which are the possible pairs to be interchanged. Choose the pair(s) of words which need to be interchanged to make the sentence grammatically correct and meaningful. 
The project has far-reaching (A) notably across cancer research, perhaps most (B) consequences in helping clinicians design treatment (C) regimens for individual cancer patients—bringing us closer to making what’s called (D) precision medicine a (E) reality.