Graduate Pharmacy Aptitude Test (GPAT) 2013 Solved Paper

Question : 65 of 125

Marks: +1, -0

Drugs that show nonlinear pharmacokinetics have which of the following property

A constant ratio of drug metabolites is formed as the administered dose increase.
The elimination half - life increasing as the administered dose increase
The area under the plasma drug concentration versus time curve increasing in direct proportion to an increase in the administered dose.
Both low and high doses follow first order elimination kinetics
The steady state drug concentration increases in direct proportion to the dosing rate

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