Graduate Pharmacy Aptitude Test (GPAT) 2009 Solved Paper

Question : 53 of 60

Marks: +1, -0

In the design of Captopril, the

−COOH group is introduced in proline to enhance the binding capability at the receptor site
-SH group is introduced to enhance the binding capability of the drug with cobalt ion of ACE
-SH group is introduced to enhance the binding to the zinc ion of ACE
−COOH and −SH groups to introduce hydrophilic pockets at the receptor site

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