GROUP I Type of inhibitor GROUP II Description (P) Competitive inhibitors 1. Have affinity only for the [ {\E}- {\S}] complex and not for the free [E] (Q) Non-competitive inhibitors 2. Binding of the inhibitor and that of the natural substrate are mutually exclusive (R) Uncompetitive inhibitors 3. Ultimately binds covalently to the enzyme (S) Suicide inhibitors 4. Binds with the same affinity to [ {\E}] and [ {\E}- {\S}]

Correct Answer is : P-2, Q-4, R-1, S-3

Graduate Pharmacy Aptitude Test (GPAT) 2009 Solved Paper

Question : 47 of 60

Marks: +1, -0

GROUP I Type of inhibitor	GROUP II Description
(P) Competitive inhibitors	1. Have affinity only for the [E−S] complex and not for the free [E]
(Q) Non-competitive inhibitors	2. Binding of the inhibitor and that of the natural substrate are mutually exclusive
(R) Uncompetitive inhibitors	3. Ultimately binds covalently to the enzyme
(S) Suicide inhibitors	4. Binds with the same affinity to [E] and [E−S]

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