Graduate Pharmacy Aptitude Test (GPAT) 2006 Solved Paper

Question : 37 of 85

Marks: +1, -0

The usefulness of 5-fluorouracil as an antitumour agent can be attributed to one of the following mechanisms

It inhibits hypoxanthine guanine phophoribosyltransferase directly
It is a prodrug that gets converted to fluoro-2'-deoxy uridylic acid, which is a suicide substarte for thymidylate synthase
It gets incorporated into RNA leading to faulty transcription and translation into non-standard Aminoacids
It gets converted into tetrafluorouridylate, whichinhibitspurin nucleoside phosphorylase

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